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Afzelin

MCE China：Afzelin

Brand：MedChemExpress (MCE)

Cat. No.HY-N1441

CAS：482-39-3

Synonyms：Kaempferol-3-O-rhamnoside

Purity：99.62%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin.

In Vitro：Afzelin (20-80 μM; 12 h) protects the viability of cardiomyocyte H9C2 cells and resists toxicity induced by DOX (1 μM; 12 h)[2].The anti-cardiotoxic effect of Afzelin is inhibited by AMPKα. Agent Dorsomorphin to eliminate[2].

In Vivo：Afzelin (5, 10 mg/kg/day; po; 20 days) attenuates DOX toxicity-induced cardiac injury in a concentration-dependent manner. Afzelin exerts cardioprotective effects by upregulating p-AMP-activated protein kinase α (AMPKα) and Sirtuin1 (SIRT1) levels[2].Afzelin (0.1-10 mg/kg/day; po; for 5 days) reduces the asthma phenotype by downregulating the GATA-binding protein 3 transcription factor (GATA3) in mouse models of asthma. Afzelin inhibits GATA3 and reduces Th2 cytokines, while GATA3 is the main regulator of Th2 cytokine differentiation and production[3].Afzelin (100 ng/μL vis icv; 3 times a week for 1 month) ameliorates synaptic plasticity and cognitive/memory behaviors in mice given Scopolamine (HY-N0296)[4].

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References：

[1]. Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209.  [Content Brief]

[2]. Sun Y, et al. Afzelin protects against doxorubicin-induced cardiotoxicity by promoting the AMPKα/SIRT1 signaling pathway. Toxicol Appl Pharmacol. 2023 Oct 15;477:116687.  [Content Brief]

[3]. Zhou W, et al. Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma. Mol Med Rep. 2015 Jul;12(1):71-6.  [Content Brief]

[4]. Oh SY, et al. Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia. Sci Rep. 2021 Apr 28;11(1):9182.  [Content Brief]