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Thymoquinone

MCE China：Thymoquinone

Brand：MedChemExpress (MCE)

Cat. No.HY-D0803

CAS：490-91-5

Purity：99.48%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

In Vitro：Thymoquinone (20-100 μM, 24-72 h) has anti-proliferation and pro-apoptotic activity in non-small cell lung cancer SCLC cell lines, and has a synergistic effect with Cisplatin (CDDP) (HY-17394) [3]. Thymoquinone (100 nM, 24 h) inhibits VEGF expression in HUVECs cells through the VEGFR2/PI3K/Akt signaling pathway[5].

In Vivo：Thymoquinone (5-20 mg/kg/day for 3 days, i.p.) can play a protective role against hepatotoxicity induced by paraquat by activating SOD inhibition mediated by paraquat[1]. Thymoquinone (10 mg/kg/day for 5 days, p.o.) can protect against Doxorubicin (HY-15142A)-induced cardiotoxicity in rats through superoxide clearance and anti-lipid peroxidation[2]. Thymoquinone (5-20 mg/kg subcutaneously (s.c.) on Monday, Wednesday and Friday for 3 weeks) alone can effectively reduce the tumor volume of NCI-H460 mouse xenograft model, overcome Cisplatin (CDDP) (HY-17394) resistance, and improve its efficacy [3]. Thymoquinone (10 or 20 mg/kg/day for 15 days, i.g.) could clear Aβ plaques and restore neuronal vitality, which could improve the memory ability of Aβ1-42 perfusion rats[4]. Thymoquinone (single 3 mg/kg, i.p.) down-regulates the VEGFR2-PI3K-Akt pathway and inhibits inflammation and new angiogenesis in asthmatic mice[5].

IC50 & Target：VEGFR2 PI3K Akt

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References：

[1]. Zeinvand-Lorestani H, et al. Protective role of thymoquinone against paraquat-induced hepatotoxicity in mice. Pestic Biochem Physiol. 2018 Jun;148:16-21.  [Content Brief]

[2]. Nagi MN, et al. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res. 2000 Mar;41(3):283-9.  [Content Brief]

[3]. Jafri SH, et al. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo. J Exp Clin Cancer Res. 2010 Jul 1;29(1):87.  [Content Brief]

[4]. Elibol B, et al. Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model. Phytomedicine. 2020 Dec;79:153324.  [Content Brief]

[5]. Su X, et al. Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice. Int Immunopharmacol. 2016 Sep;38:70-80.  [Content Brief]