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MedChemExpress - Model Nervonic acid -506-37-6
Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases[1][2][3].MCE products for research use only. We do not sell to patients.
Nervonic acid
MCE China:Nervonic acid
Brand:MedChemExpress (MCE)
Cat. No.HY-N2526
CAS:506-37-6
Synonyms:Selacholeic acid; cis-15-Tetracosenoic acid
Purity:99.95%
Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases.
In Vitro:Nervonic acid (0.01 μM, 48 h) can improve the activity of PC-12 cells and play a role as a neuroprotective mediator in the brain[1]. Nervonic acid (12.5, 25, 50 μM, 24 h) can decrease the inflammatory response of RAW264.7 cells induced by LPS and inhibit the activation of key signal pathways related to inflammation[3].
In Vivo:Nervonic acid (20, 40, 60 mg/kg, gavage for 7 days) protects the motor system against motor disorders in a PD mouse model[2]. Nervonic acid (5, 50, 100 mg/kg, dissolved in corn oil for 7 days) improves colonic inflammation by inhibiting the NF-κB signaling pathway in DSS-induced colitis mice[3].
IC50 & Target:Human Endogenous Metabolite
Hot selling product:Gemcitabine | 4-Hydroxytamoxifen | Metformin | Obeticholic acid | MS67 | Sorafenib | Mitoquinone (mesylate) | Niraparib | Everolimus | Capsaicin
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References:
[1]. Umemoto H, et al. Protective Effect of Nervonic Acid Against 6-Hydroxydopamine-Induced Oxidative Stress in PC-12 Cells. J Oleo Sci. 2021;70(1):95-102. [Content Brief]
[2]. Hu D, et al. Nervonic acid amends motor disorder in a mouse model of Parkinson's disease. Transl Neurosci. 2022 Apr 20;13(1):71. [Content Brief]
[3]. Yuan SN, et al. Improved colonic inflammation by nervonic acid via inhibition of NF-κB signaling pathway of DSS-induced colitis mice. Phytomedicine. 2023 Apr;112:154702. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
