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MedChemExpressModel Beta-asarone -5273-86-9

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Beta-asarone is an orally active and BBB-penatrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases[1][2][3][4].
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Beta-asarone

MCE China:Beta-asarone

Brand:MedChemExpress (MCE)

Cat. No.HY-N1501

CAS:5273-86-9

Purity:99.87%

Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Beta-asarone is an orally active and BBB-penatrable anti-inflammatory agent and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. Beta-asarone can protect nerve cells from apoptosis and autophagy, as well as myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases.

In Vitro:Beta-asarone (7.5-30 μg/mL; 25 h) can protect PC12 cells against Aβ1-42 induced cytotoxicity and autophagy[1]. Beta-asarone (100 μM; 2 h) inhibits the up-regulation of MALAT1 and α-synuclein expression in SH-SY5Y cells treated with MPP+ (HY-W008719)[2].

In Vivo:Beta-asarone (intragastric administration; 10 mg/kg; 28 days) exhibits a neuroprotective effect in a mouse model of Parkinson's disease[2]. Beta-asarone (oral administration; 12.5-50 mg/kg; 28 days) alleviates Aβ1–42-induced apoptosis of hippocampal neurons in a rat model of Alzheimer's disease[3]. Beta-asarone (intraperitoneal injection; 10-30 mg/kg; single dose) has anti-inflammatory and protective effects in a rat model of myocardial ischemia-reperfusion[4].

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References:

[1]. Xue Z, et al. Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells. Eur J Pharmacol. 2014 Oct 15;741:195-204.  [Content Brief]

[2]. Zhang QS, et al. Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression. Biomed Pharmacother. 2016 Oct;83:153-159.  [Content Brief]

[3]. Liu J, et al. Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus. Yakugaku Zasshi. 2010 May;130(5):737-46.  [Content Brief]

[4]. Xiao B, et al. Beta-Asarone Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis. Biol Pharm Bull. 2020 Jul 1;43(7):1046-1051.  [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
•   It has a professional experimental center and strict quality control and verification system;
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
•   The biological activity of the products has been verified by the experiments of customers in various countries;
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。