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MedChemExpress - Model Scutellarein -529-53-3
Scutellarein is a natural flavonoid compound with anti-inflammatory effects.MCE products for research use only. We do not sell to patients.
Scutellarein
MCE China：Scutellarein
Brand：MedChemExpress (MCE)
Cat. No.HY-N0752
CAS：529-53-3
Synonyms：6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone
Purity：99.25%
Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Scutellarein is a natural flavonoid compound with anti-inflammatory effects.
In Vitro：Scutellarein (0-200 μM, 24 h) inhibits NO production, reduces the mRNA expression levels of iNOS and TNF-α in LPS-activated RAW264.7 cells[1]. Scutellarein (0-50 μM, 24 h) inhibits proliferation, migration, colony formation and induces the apoptosis of HT1080 cells[3]. Scutellarein (0-50 μM, 24 h) inhibits MMP-2, -9 and -14 expression and NF-κB activation in HT1080 cells[3]. Scutellarein shows DPPH, ABTS+·, ·OH radical-scavenging activity (IC50: 16.84 μM, 3.00 μM, 0.31 mM respectively)[4].
In Vivo：Scutellarein (50 mg/kg, in diet, 16 weeks) shows anti-obesity effects, and shows lipid lowering and liver protective effects in HFD mice[2]. Scutellarein (50 and 500 mg/kg) inhibits tumor growth in a mouse HT108 xenograft model[3]. Scutellarein (0-1.40 mmol/kg, p.o.) improves neuronal injury, and protects rats from cerebral ischemia[5].
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Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References：
[2]. Lin Y, et al. Novel anti-obesity effect of scutellarein and potential underlying mechanism of actions. Biomed Pharmacother. 2019 Sep;117:109042. [Content Brief]
[3]. Shi X, et al. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. Int J Mol Med. 2015 Jan;35(1):31-8. [Content Brief]
[4]. Qian LH, et al. Synthesis and bio-activity evaluation of scutellarein as a potent agent for the therapy of ischemic cerebrovascular disease. Int J Mol Sci. 2011;12(11):8208-16. [Content Brief]
[5]. Tang H, et al. Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats. Pharmacol Biochem Behav. 2014 Mar;118:51-9. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。