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MedChemExpressModel PF-4878691 -532959-63-0

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PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer[1][2].
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PF-4878691

MCE China:PF-4878691

Brand:MedChemExpress (MCE)

Cat. No.HY-100176

CAS:532959-63-0

Synonyms:3M-852A

Purity:99.64%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping:Room temperature in continental US; may vary elsewhere.

Description:PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer.

In Vitro:PF-4878691 (10 μM, 4 h) induces a complex transcription network responsible for activating plasmacytoid dendritic cells for innate antiviral immune responses with optimized responses towards RNA viruses, increases co-stimulatory capacity, and increases survival in plasmacytoid dendritic cells[2].

In Vivo:PF-4878691 (10-150 mg, Oral gavage, single dose) induces pharmacology in BALB/c mice and C57bl/6 J mice[1].

IC50 & Target:TLR7 IL-6 IL-8 IL-1β IL-2

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References:

[1]. Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9.  [Content Brief]

[2]. Birmachu W, et al. Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists [J]. BMC immunology, 2007, 8: 1-19.

[3]. Horscroft NJ, et al. Antiviral applications of Toll-like receptor agonists. J Antimicrob Chemother. 2012 Apr;67(4):789-801.  [Content Brief]

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