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MedChemExpressModel Droperidol -548-73-2

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Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist that inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR), with IC50 values of 12.6 nM and 5.8 μM. Droperidol has anesthetic and sedative properties[1][2].
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Droperidol

MCE China:Droperidol

Brand:MedChemExpress (MCE)

Cat. No.HY-B1240

CAS:548-73-2

Synonyms:Dehydrobenzperidol

Purity:99.90%

Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist that inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR), with IC50 values of 12.6 nM and 5.8 μM. Droperidol has anesthetic and sedative properties.

In Vitro:Doperidol (100 μM) activates the GABAA receptor in the absence of GABA[1].

In Vivo:Doperidol (0.125-4 mg/kg, intravenous injection, single dose) can slow down a dog's breathing, heart rate, and reduce blood pressure, cardiac output, and myocardial contractility[2].

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References:

[1]. Pamela Flood, et al. Droperidol inhibits GABA(A) and neuronal nicotinic receptor activation. Anesthesiology. 2002 Apr;96(4):987-93.  [Content Brief]

[2]. J YELNOSKY, et al. A STUDY OF SOME OF THE PHARMACOLOGIC ACTIONS OF DROPERIDOL. Toxicol Appl Pharmacol. 1964 Jan:5:37-47.  [Content Brief]

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