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MedChemExpress - Model Droperidol -548-73-2
Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist that inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR), with IC50 values of 12.6 nM and 5.8 μM. Droperidol has anesthetic and sedative properties[1][2].MCE products for research use only. We do not sell to patients.
Droperidol
MCE China:Droperidol
Brand:MedChemExpress (MCE)
Cat. No.HY-B1240
CAS:548-73-2
Synonyms:Dehydrobenzperidol
Purity:99.90%
Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist that inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR), with IC50 values of 12.6 nM and 5.8 μM. Droperidol has anesthetic and sedative properties.
In Vitro:Doperidol (100 μM) activates the GABAA receptor in the absence of GABA[1].
In Vivo:Doperidol (0.125-4 mg/kg, intravenous injection, single dose) can slow down a dog's breathing, heart rate, and reduce blood pressure, cardiac output, and myocardial contractility[2].
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References:
[1]. Pamela Flood, et al. Droperidol inhibits GABA(A) and neuronal nicotinic receptor activation. Anesthesiology. 2002 Apr;96(4):987-93. [Content Brief]
[2]. J YELNOSKY, et al. A STUDY OF SOME OF THE PHARMACOLOGIC ACTIONS OF DROPERIDOL. Toxicol Appl Pharmacol. 1964 Jan:5:37-47. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
