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3-Hydroxyanthranilic acid

MCE China：3-Hydroxyanthranilic acid

Brand：MedChemExpress (MCE)

Cat. No.HY-W001171

CAS：548-93-6

Purity：99.73%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.3-hydroxyanthranilic acid has anti-inflammatory, neuroprotective, and lipid-lowering effects. 3-hydroxyanthranilic acid can be used for researches of cardiovascular diseases, tumors, and metabolic diseases.

In Vitro：3-hydroxyanthranilic acid (12.5-100 μM, 24-72 h) selectively induces activated T cell death via intracellular GSH depletion[2]. 3-hydroxyanthranilic acid (100-200 μM, 6 h) reduces ability of BMDCs stimulated with LPS to produce cytokines (IL-12, IL-6, and TNF-α) and DC maturation[3]. 3-hydroxyanthranilic acid (0-100 μM, 1-72 h) plays anti-inflammatory and neuroprotective roles via Hemeoxygenase-1 in primary human fetal central nervous system cultures[4]. 3-hydroxyanthranilic acid (1-50 μM, 6 h) inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells[6].

In Vivo：3-hydroxyanthranilic acid (40 μg/each mouse, injected intracerebrally into the forebrains) can induce HO-1 in 8-week-old C57BL6 mice[4]. 3-hydroxyanthranilic acid (200 mg/kg, i.p., three times a week, 8 weeks) lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice[5]. 3-hydroxyanthranilic acid (200 mg/kg, i.p., 6 weeks) contributes to angiotensin II–induced abdominal aortic aneurysm formation in mice[7]. 3-hydroxyanthranilic acid (120 mg/kg, tail vein injection, once weekly, 12 weeks) combines with Butyricicoccus pullicaecorum to prevent postmenopausal osteoporosis in rats by modulating gut microbiota and Th17/Treg[8].

IC50 & Target：Human Endogenous Metabolite

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References：

[1]. Lee WS, et al. The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation. Int Immunopharmacol. 2013 Nov;17(3):721-6.  [Content Brief]

[2]. Lee SM, et al. Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion. Immunol Lett. 2010 Aug 16;132(1-2):53-60.  [Content Brief]

[3]. Lee WS, et al. The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation. Int Immunopharmacol. 2013 Nov;17(3):721-6.  [Content Brief]

[4]. Krause D, et al. The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1. Am J Pathol. 2011 Sep;179(3):1360-72.  [Content Brief]

[5]. Zhang L, et al. The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice. Eur Heart J. 2012 Aug;33(16):2025-34.  [Content Brief]

[6]. Pae HO, et al. 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells. Atherosclerosis. 2006 Aug;187(2):274-84.  [Content Brief]

[7]. Wang Q, et al. Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo. Circulation. 2017 Dec 5;136(23):2271-2283.  [Content Brief]

[8]. Zhu F, et al. The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg. Eur J Nutr. 2024 Aug;63(5):1945-1959.  [Content Brief]