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MedChemExpress - Model Narasin - ...

MedChemExpress - Model Narasin -55134-13-9

Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL‑6/STAT3 signaling pathways[1][2][3].

Narasin

MCE China：Narasin

Brand：MedChemExpress (MCE)

Cat. No.HY-121410

CAS：55134-13-9

Purity：88.0%

Storage：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL‑6/STAT3 signaling pathways.

In Vitro：Narasin (1-25 ng/mL, 48 h) increases the percentage of phosphatidylserine exposing erythrocytes, cytosolic Ca2+ activity ([Ca2+]i) and the ceramide abundance at the erythrocyte surface[1]. Narasin (0-10 μM, 72 h) inhibits DENV2 infection with an IC50 value of 0.39 μM[2]. Narasin (0-10 μM, 72 h) significantly inhibits the cell viability of MCF-7, T47D and MDA-MB-231 cells, with respective IC50 values of 2.219, 3.562 and 11.76 µM[3]. Narasin (2.5-5 µM, 24 h) inhibits cell migration and invasion by suppressing EMT in ER+ BC cells[3].

In Vivo：Narasin (0.5 mg/kg or 1.5 mg/kg; i.p., every 2 days for 50 consecutive days) inhibits tumor growth and angiogenesis in xenograft mice model with MCF-7 cells[3].

IC50 & Target：Coccidia

References：

[1]. Ghada Bouguerra, et al. Stimulation of Eryptosis by Narasin. Cell Physiol Biochem. 2015;37(5):1807-16. [Content Brief]

[2]. Low JS, et al. Narasin, a novel antiviral compound that blocks dengue virus protein expression. Antivir Ther. 2011;16(8):1203-18. [Content Brief]

[3]. Chen J, et al. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF‑β/SMAD3 and IL‑6/STAT3 signaling pathways. Mol Med Rep. 2020 Dec;22(6):5113-5124. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
•   More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
•   The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
•   It has a professional experimental center and strict quality control and verification system；
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
•   The biological activity of the products has been verified by the experiments of customers in various countries；
•   A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。

MedChemExpress - Model Narasin -55134-13-9

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Narasin