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Phytosphingosine

MCE China：Phytosphingosine

Brand：MedChemExpress (MCE)

Cat. No.HY-W011303

CAS：554-62-1

Synonyms：4-Hydroxysphinganine

Purity：98.0%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes.

In Vitro：Phytosphingosine (200-400 μg/mL; 60-240 min) can inhibit the growth of Gram-positive and Gram-negative bacteria, yeast, and molds, and significantly inhibit the release of IL-1a, exhibiting anti-inflammatory activity[1]. Phytosphingosine (1-5 μg/mL; 24-48 h) inhibits lung adenoma cell proliferation by inducing G2/M phase arrest, apoptosis and mitochondria-dependent pathway cell death in A549 and LLC cells, with IC50 values of 4.3 μg/mL and 4.5μg/mL, respectively[2]. Phytosphingosine (80 μM; 1-10 days) has antibacterial activity and can inhibit the growth ofS. sclerotiorum, S. indica and V. longisporum[3].

In Vivo：Phytosphingosine (0.5-2 mg/kg; Intraperitoneal injection; once every other day for 10 times) has anti-tumor activity in C57BL/6 mice with lung cancer[2].

IC50 & Target：Human Endogenous Metabolite

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References：

[1]. 1. Pavicic T, Wollenweber U, Farwick M, et al. Anti‐microbial and‐inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris[J]. International journal of cosmetic science, 2007, 29(3): 181-190.  [Content Brief]

[2]. Cai Q, et al. Phytosphingosine inhibits the growth of lung adenocarcinoma cells by inducing G2/M-phase arrest, apoptosis, and mitochondria-dependent pathway cell death in vitro and in vivo. Chem Biol Interact. 2024 Jan 5;387:110795.  [Content Brief]

[3]. Glenz R, et al. The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens. Sci Rep. 2022 Jan 20;12(1):1081.  [Content Brief]

[4]. Nagasawa T, et al. Phytosphingosine is a novel activator of GPR120. J Biochem. 2018 Jul 1;164(1):27-32.  [Content Brief]