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Hispidin

MCE China：Hispidin

Brand：MedChemExpress (MCE)

Cat. No.HY-100618

CAS：555-55-5

Purity：99.94%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Hispidin, a PKC inhibitor and a phenolic compound can be found in Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties.

In Vitro：Hispidin (20 μM, 24 hours) alleviates ferroptosis and improves pancreatic β-cell function (as evidenced by the inhibition of ROS, Fe²⁺, and MDA accumulation, along with an increase in GSH levels), primarily exerting its protective effects through the regulation of the miR-15b-5p/GLS2 axis[2].Hispidin (20 μg/ml, 24 hours) mitigates LPS (HY-D1056)-induced inflammatory responses in macrophages by inhibiting the phosphorylation of the MAPK and JAK1/STAT3 signaling pathways[3].Hispidin (20 µM, 25 hours) protects dopaminergic neurons from JNK activation-regulated mitochondrial-dependent apoptosis[4].Hispidin (3-30 μM, 7 hours) protects against hydrogen peroxide-induced apoptosis in H9c2 cardiomyocytes via the Akt/GSK-3β and ERK1/2 signaling pathways[5].Hispidin (2.5-20 μM, 24 hours) exerts a protective effect against hydrogen peroxide-induced oxidative stress in ARPE-19 cells through the Nrf2 signaling pathway[6].

In Vivo：Hispidin (2.5%-5% Hispidin ointment, topical application, 0.2 g per day for 14 days) promotes wound healing in Wistar rats, acting via anti-inflammatory, antioxidant, and tissue regeneration mechanisms[7].

IC50 & Target：Microbial Metabolite

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References：

[1]. Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327(2):264-75.  [Content Brief]

[2]. Wu F, et al. Hispidin Inhibits Ferroptosis Induced by High Glucose via the miR-15b-5p/GLS2 Axis in Pancreatic Beta Cells. Evid Based Complement Alternat Med. 2023 Feb 21;2023:9428241.  [Content Brief]

[3]. Han Y H, et al. Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways[J]. Applied Biological Chemistry, 2020, 63: 1-9.

[4]. Lai MC, et al. Hispidin in the Medicinal Fungus Protects Dopaminergic Neurons from JNK Activation-Regulated Mitochondrial-Dependent Apoptosis in an MPP+-Induced In Vitro Model of Parkinson's Disease. Nutrients. 2023 Jan 20;15(3):549.  [Content Brief]

[5]. Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327(2):264-75.  [Content Brief]

[6]. Huang SY, et al. The Protective Effect of Hispidin against Hydrogen Peroxide-Induced Oxidative Stress in ARPE-19 Cells via Nrf2 Signaling Pathway. Biomolecules. 2019 Aug 19;9(8):380.  [Content Brief]

[7]. Liu YS, et al. Exploring the Wound Healing Potential of Hispidin. Nutrients. 2024 Sep 19;16(18):3161.  [Content Brief]