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Acesulfame potassium

MCE China：Acesulfame potassium

Brand：MedChemExpress (MCE)

Cat. No.HY-D0195

CAS：55589-62-3

Purity：99.38%

Storage：-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Acesulfame potassium is a synthetic sweetener. Long-term use of Acesulfame potassium can affect cognitive function, possibly by altering the neurometabolic functions in mice. Acesulfame potassium can suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells through the ERK1/2-mTORC1-ULK1 pathway, which may be related to immune evasion in cancer cells. Acesulfame potassium can be used in research on neurological diseases, metabolic disorders, cancer, and immune evasion.

In Vitro：Acesulfame potassium (1 mM, 24 hours) upregulates PD-L1 protein levels in RIL-175 and SK-Hep1 cells[2]. Acesulfame potassium (1 mM, 24 hours) increases granzyme B production in RIL-175 and SK-Hep1 cells co-cultured with T cells[2]. Acesulfame potassium (1 mM, 24 hours) activates ERK1/2-mTORC1-ULK1 pathway to suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells[2]. Acesulfame potassium (5-25 mM, 24 hours) inhibites mitochondrial metabolism in SH-SY5Y cells[4]. Acesulfame potassium (5-25 mM, 24 hours) inhibites ATP production in cells and reduced phosphorylation of neuroprotective proteins, impaires energy metabolism and neuroprotective functions in SH-SY5Y cells[4].

In Vivo：Acesulfame potassium (37.5 mg/kg, p.o., once daily for 4 weeks) increases body weight in male CD-1 mice and altered their gut microbiome composition[3]. Long-term intake of Acesulfame potassium (12.5 mM, administered via drinking water for 40 weeks) affects the neurometabolic functions in C57BL/6J mice[4].

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References：

[1]. Cong WN, et al. Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice. PLoS One. 2013 Aug 7;8(8):e70257.  [Content Brief]

[2]. Kim DH, et al. Acesulfame potassium upregulates PD-L1 in HCC cells by attenuating autophagic degradation. Biochem Biophys Res Commun. 2024 Jun 4;711:149921.  [Content Brief]

[3]. Bian X, et al. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One. 2017 Jun 8;12(6):e0178426.  [Content Brief]

[4]. Cong WN, et al. Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice. PLoS One. 2013 Aug 7;8(8):e70257.  [Content Brief]