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Glycine

MCE China：Glycine

Brand：MedChemExpress (MCE)

Cat. No.HY-Y0966

CAS：56-40-6

Purity：99.93%

Storage：Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis.

In Vitro：Glycine (0-1 mM, 0-48 h) has anti-tumor and anti-angiogenic effects. It can downregulate the production of VEGF in tumor cells HCT-116, HT-29 and CC-531, inhibit the growth of endothelial cells HUVEC through GlyR, and indirectly inhibit HUVEC migration and capillary formation[3]. Glycine (5 mM, 50 mM, 10 min) can prevent the aggregation of NINJ1 in the plasma membrane and inhibit cell death caused by the breakdown of NINJ1 dependent property membrane, thereby exerting its cytoprotective effect[4].

In Vivo：Glycine (single 40-800 mg/kg, i.p.) dose-dependently prevents scopolamine (HY-N0296)-induced social cognitive impairment in adult rats[2]. Glycine (500 and 1000 mg/kg/day for 14 days, i.p.) can significantly reduce kidney damage in lead-exposed mice by inhibiting ROS production[5]. Glycine (single 1 or 2 g/kg, p.o.) increases extracellular serotonin but not dopamine in the prefrontal cortex of rats

IC50 & Target：NMDA Receptor Human Endogenous Metabolite Microbial Metabolite NINJ1

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References：

[1]. Johnson JW, et al. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987 Feb 5-11;325(6104):529-31.  [Content Brief]

[2]. Fone KCF, et al. Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management. Mol Neurobiol. 2020 May;57(5):2144-2166.  [Content Brief]

[3]. Bruns H, et al. Glycine inhibits angiogenesis in colorectal cancer: role of endothelial cells. Amino Acids. 2016 Nov;48(11):2549-2558.  [Content Brief]

[4]. Borges JP, et al. Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death. Elife. 2022 Dec 5;11:e78609.  [Content Brief]

[5]. Shafiekhani M, et al. Glycine supplementation mitigates lead-induced renal injury in mice. J Exp Pharmacol. 2019 Feb 18;11:15-22.  [Content Brief]

[6]. Bannai M, et al. Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats. Psychiatry Clin Neurosci. 2011 Mar;65(2):142-9.  [Content Brief]