MedChemExpress - Model Afloqualone -56287-74-2
Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome[1][2][3].MCE products for research use only. We do not sell to patients.
Afloqualone
MCE China：Afloqualone
Brand：MedChemExpress (MCE)
Cat. No.HY-B1833
CAS：56287-74-2
Synonyms：HQ-495
Purity：99.94%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome.
In Vivo：Afloqualone (intravenous injection; 5-20 mg/kg; single dose) inhibits the mono-synaptic and poly-synaptic reflex potentials in a dose-dependent manner in spinalized cats[1]. Afloqualone (oral administration; 10-35 mg/kg; single dose) can relax γ-rigidity and α-rigidity in rats in a dose-dependent manner[1]. Afloqualone (oral administration; 5-10 mg/kg; single dose) inhibits vestibular nystagmus in a dose-dependent manner in spinalized cats[2].
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References：
[1]. T Ochiai, et al. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32(3):427-38. [Content Brief]
[2]. Y Kudo, et al. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Jpn J Pharmacol. 1989 Aug;50(4):515-9. [Content Brief]
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