MCE products for research use only. We do not sell to patients.

Lipoteichoic acid

MCE China：Lipoteichoic acid

Brand：MedChemExpress (MCE)

Cat. No.HY-N9481

CAS：56411-57-5

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Lipoteichoic acid is an orally effect anti-inflammatory and antitumor agent. Lipoteichoic acid is a crucial immune molecule in Gram-positive bacteria that activates the complement system by inducing C3 and inhibiting CD55. Lipoteichoic acid regulates macrophage autophagy through the PI3K/Akt/mTOR pathway. Lipoteichoic acid induces lung damage in mice. Lipoteichoic acid inhibits the production of melanin.

In Vitro：Lipoteichoic acid (0.1-20 μg/mL; 12-48 h) induces macrophage autophagy by inhibiting PI3K/AKT/mTOR pathway[2]. Lipoteichoic acid (0.1-100 μg/mL; 24 h) inhibits the production of melanin in B16F10 cells through MITF, ERK and PI3K/AKT signaling pathways[3]. Lipoteichoic acid (50-100 ng/mL; 2-3 h) shows no cytotoxicity to HT-29 cells, decreases the secretion of TNF-α and increases the secretion of IL-10 in HT-29 cells treated with LPS (HY-D1056)[4].

In Vivo：Lipoteichoic acid (800 μg/100 μL; Oral gavage; 7 days) shows improvement in colitis mouse model[4]. Lipoteichoic acid (0.1 mg; Oral administration; 20 days-34 weeks) has immunomodulatory and protective effects in UV-induced tumor models[5]. Lipoteichoic acid (5 mg/kg; Intratracheal injection; Single dose) can induce lung injury in mice[6].

Hot selling product：Doxorubicin (hydrochloride)  | Trastuzumab  | Bleomycin (sulfate)  | Bleomycin (hydrochloride)  | Bevacizumab  | Puromycin (dihydrochloride)  | Trastuzumab deruxtecan  | Ionomycin  | Chloroquine  | Cisplatin

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Bong Jun Jung, et al. Lipoteichoic Acid from Staphylococcus aureus Activates the Complement System via C3 Induction and CD55 Inhibition. Microorganisms. 2021 May 24;9(6):1135.  [Content Brief]

[2]. Lin D, et al. Enterococcus faecalis lipoteichoic acid regulates macrophages autophagy via PI3K/Akt/mTOR pathway. Biochem Biophys Res Commun. 2018 Apr 15;498(4):1028-1036.  [Content Brief]

[3]. Kim HR, et al. Lipoteichoic acid isolated from Lactobacillus plantarum inhibits melanogenesis in B16F10 mouse melanoma cells. Mol Cells. 2015;38(2):163-70.  [Content Brief]

[4]. Pradhan D, et al. Postbiotic Lipoteichoic acid of probiotic Lactobacillus origin ameliorates inflammation in HT-29 cells and colitis mice. Int J Biol Macromol. 2023 May 1;236:123962.  [Content Brief]

[5]. Weill FS, et al. Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against UV-induced carcinogenesis. Br J Nutr. 2013 Feb 14;109(3):457-66.  [Content Brief]

[6]. Zhang Y, et al Shikonin ameliorates lipoteichoic acid induced acute lung injury via promotion of neutrophil apoptosis. Mol Med Rep. 2021 Feb;23(2):133.  [Content Brief]

[7]. Hara H, et al. The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018 Nov 29;175(6):1651-1664.e14.  [Content Brief]