MCE products for research use only. We do not sell to patients.

Decursin

MCE China：Decursin

Brand：MedChemExpress (MCE)

Cat. No.HY-18981

CAS：5928-25-6

Synonyms：(+)-Decursin

Purity：99.99%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities.

In Vitro：Decursin (0, 25, 50, 100 μM; 24, 28, 72, 96 h) inhibits cell growth in a dose- and time- dependent manner in DU145 cells[1]. Decursin (0, 25, 50, 100 μM; 24, 28, 72, 96 h) induces apoptosis and cell cycle arrest at G1 phase in DU145 cells, G1, S as well as G2-M arrests in PC-3 cells[1]. Decursin (0, 25, 50, 100 μM; 24, 48 h) decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h in DU145 cells[1]. Decursin (0, 5, 20, 100 μM; 7 days) inhibits the proliferation and differentiation ability of AC133+ cells[2]. Decursin (0, 5, 20, 100 μM) inhibits SDF-1a-induced activation of Akt, ERK1/2, and eNOS in a dose-dependent manner[2].

In Vivo：Decursin (4 mg/kg; s.c.; daily for 4 weeks) shows anti-tumor activity in mouse[2]. Decursin (50 mg/kg; intrathecal injection; three times at 2-day intervals, for 6 days) shows analgesic ability in paclitaxel-induced peripheral neuropathy in mouse[3].

Hot selling product：Azomycin  | Ambroxol  | Proguanil  | ZQ-16  | S-Methylisothiourea (sulfate)  | Methyl palmitate  | Bellidifolin  | Phospho-AKT (Thr308) Antibody  | Ethylenediaminetetraacetic acid (disodium dihydrate)  | Clebopride (malate)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

References：

[1]. Yim D, et al. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 2005 Feb 1;65(3):1035-44.  [Content Brief]

[2]. Jung SY, et al. Decursin inhibits vasculogenesis in early tumor progression by suppression of endothelial progenitor cell differentiation and function. J Cell Biochem. 2012 May;113(5):1478-87.  [Content Brief]

[3]. Son DB, et al. Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model. Cells. 2021 Mar 4;10(3):547.  [Content Brief]

[4]. Ahn KS, et al. Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med. 1996 Feb;62(1):7-9.  [Content Brief]