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MedChemExpress - Model Diethyl phosphate -598-02-7
Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats[1][2][3].MCE products for research use only. We do not sell to patients.
Diethyl phosphate
MCE China：Diethyl phosphate
Brand：MedChemExpress (MCE)
Cat. No.HY-101417
CAS：598-02-7
Synonyms：Diethyl phosphoric acid
Purity：98.0%
Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats.
In Vitro：Diethyl phosphate can interact with thyroid hormone biosynthesis, blood transport, receptor binding and metabolism-related enzymes/proteins, interfering with the production and signal regulation of thyroid hormones in silico[1].
In Vivo：Diethyl phosphate (oral gavage; 0.08-0.8 mg/kg; 24 weeks) can lead to the disturbance of endocrine hormones and related metabolic indexes in rats[1]. Diethyl phosphate (oral gavage; 0.08-0.13 mg/kg; 20 weeks) affects the intestinal microbiota, serum hormones and pro-inflammatory cytokines[2].
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References：
[1]. Yang FW, et al. Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches. Environ Int. 2020 Feb;135:105383. [Content Brief]
[2]. Yang F, et al. Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota. Molecules. 2019 May 24;24(10):2003. [Content Brief]
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