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MedChemExpress - Model Ethyl pyruvate -617-35-6
Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity. Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease[1][2][3][4][5].MCE products for research use only. We do not sell to patients.
Ethyl pyruvate
MCE China：Ethyl pyruvate
Brand：MedChemExpress (MCE)
Cat. No.HY-Y1362
CAS：617-35-6
Purity：99.00%
Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity. Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
In Vitro：Ethyl pyruvate (10 mM, 1 h) has no toxic effect on N9 microglial cells in the range of 1-10 mM. The activation of microglia NLRP3 inflammasome is decreased by inhibiting the HMGB1/ NF-κB /miR-223 signaling pathway[2]. Ethyl pyruvate (10-40 mM, 6, 24 h) induces apoptosis in MC38 cells[3]. Ethyl pyruvate (5-15 mM, 2 h) has an IC50 value of 28.83 mM on mouse peritoneal macrophages. Endotoxemia and sepsis are prevented by inhibiting caspase-11-dependent pyroptosis [4].
In Vivo：Ethyl pyruvate (80 mg/kg intraperitoneal injection for 9 consecutive days) inhibits tumor growth in a mouse liver tumor model[3]. Ethyl pyruvate (2 or 40 mg/kg, intraperitoneal injection) has reduced lipid peroxidation and anti-inflammatory effects in a rat model of paraquat intoxication[5].
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References：
[1]. Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med. 2007 Apr;261(4):349-62. [Content Brief]
[2]. Olcum M, Tufekci KU, Durur DY, et al. Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-κB/miR-223 Signaling. Antioxidants (Basel). 2021;10(5):745. [Content Brief]
[3]. Liang X, et al. Ethyl pyruvate administration inhibits hepatic tumor growth. J Leukoc Biol. 2009 Sep;86(3):599-607. [Content Brief]
[4]. Qiu X, et al. Ethyl pyruvate confers protection against endotoxemia and sepsis by inhibiting caspase-11-dependent cell pyroptosis. Int Immunopharmacol. 2020 Jan;78:106016. [Content Brief]
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