MedChemExpress - Model Helichrysetin -62014-87-3
Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity[1][2][3].MCE products for research use only. We do not sell to patients.
Helichrysetin
MCE China：Helichrysetin
Brand：MedChemExpress (MCE)
Cat. No.HY-N4058
CAS：62014-87-3
Purity：99.92%
Storage：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity.
In Vitro：Helichrysetin (0-100 μM, 48 h) inhibits the development of ductal carcinoma in situ (DCIS) by targeting DNA inhibitor 2 (ID2) [2]. Helichrysetin (5-20 μg/mL, 48 h) can block the cell cycle and induce apoptosis in A549 human lung cancer cells[2]. Helichrysetin (10-40 μM, 48 h) inhibits the growth of gastric cancer cells by targeting mTOR/p70S6K/c-Myc/ PDHK1-mediated energy metabolic reprogramming of cancer cells[3].
In Vivo：Helichrysetin (10 mg/kg, Intraperitoneal injection) can inhibit DCIS growth in mice with no obvious side effects[1]. Helichrysetin (3, 10, 30 mg/kg, Intraperitoneal injection) can inhibit tumor growth in a mouse model of gastric cancer cell transplantation[3].
Hot selling product：Mosunetuzumab | DSPE-PEG 2000 | Ribociclib | Canagliflozin | Orlistat | Mitapivat | Abiraterone | Napabucasin | SBI-115 | Sodium 9-oxobutanoate
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References：
[1]. Liu Y, et al. ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness. Breast Cancer Res Treat. 2019 May;175(1):77-90. [Content Brief]
[2]. Ho YF, et al. Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells. Evid Based Complement Alternat Med. 2013;2013:857257. [Content Brief]
[3]. Wang P, et al. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming. Acta Pharmacol Sin. 2022 Jun;43(6):1581-1593. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。