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MedChemExpressModel Ursonic acid -6246-46-4

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Ursolic acid is a naturally occurring triterpenoid that has orally active. Ursolic acid induces the apoptosis of human cancer cells through multiple signaling pathways. Ursolic acid has anti-inflammatory and anticarcinogenic activity[1][2].
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Ursonic acid

MCE China:Ursonic acid

Brand:MedChemExpress (MCE)

Cat. No.HY-N1486

CAS:6246-46-4

Synonyms:3-Ketoursolic acid

Purity:98.15%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Ursolic acid is a naturally occurring triterpenoid that has orally active. Ursolic acid induces the apoptosis of human cancer cells through multiple signaling pathways. Ursolic acid has anti-inflammatory and anticarcinogenic activity.

In Vitro:Ursolic acid (12.5-50 μM, 48 h) induce apoptosis in T24 human bladder cancer cells in a dose-dependent manner by inhibiting AKT/NF-κB signaling[1]. Ursolic acid (50 μM, 2-4 h) increases the expression of p53 and caspase-3 and decreases bcl-2 gene expression in B16F-10 melanoma cells[2]. Ursolic acid (10-50 μM, 48 h) inhibits the production of TNF-α, IL-1β, IL-6 and GM-CSF in B16F-10 melanoma cells[2]. Ursolic acid (50 μM, 2 h) inhibits the NF-κB subunits (p65, p50 and c-Rel) and nuclear translocation of c-fos, ATF-2 and CREB-1 in B16F-10 melanoma cells[2].

In Vivo:Ursolic acid (5-20 mg/kg, p.o., twice a day, 30 days) protects against ethanol-mediated experimental liver injury in adult male albino rats[3].

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References:

[1]. Gai, L., Cai, N., Wang, L., Xu, X. & Kong, X. Ursolic acid induces apoptosis via Akt/NF-kappaB signaling suppression in T24 human bladder cancer cells. Molecular medicine reports 7, 1673-1677, doi:10.3892/mmr.2013.1364 (2013).  [Content Brief]

[2]. Manu, K. A. & Kuttan, G. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells. International immunopharmacology 8, 974-981, doi:10.1016/j.intimp.2008.02.013 (2008).  [Content Brief]

[3]. Saravanan R, et al. Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats. Life Sci. 2006 Jan 11;78(7):713-8.  [Content Brief]

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