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MedChemExpress - Model Meglumine (Excipient) -6284-40-8
Meglumine (Methylglucamine) (Excipient) is an orally active amino sugar derived from sorbitol. Meglumine (Excipient) has anti-inflammatory and antitumor activity. Meglumine (Excipient) is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide[1][2][3].MCE products for research use only. We do not sell to patients.
Meglumine (Excipient)
MCE China：Meglumine (Excipient)
Brand：MedChemExpress (MCE)
Cat. No.HY-B0342A
CAS：6284-40-8
Synonyms：Methylglucamine (Excipient); Meglumin (Excipient); Methylglucamin (Excipient)
Storage：Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Meglumine (Methylglucamine) (Excipient) is an orally active amino sugar derived from sorbitol. Meglumine (Excipient) has anti-inflammatory and antitumor activity. Meglumine (Excipient) is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide.
In Vitro：Meglumine (Excipient) (40 or 80 mM, 24 h; 50 mM, 24 h) dose-dependently reduces the levels of inflammatory factors in THP-1 human myeloid cells and RAW264.7 mouse macrophage cells (Elisa assay)[2]. Meglumine (Excipient) (0-300 mM, 60 min) dose-dependently increases SNARK expression levels in C2C12 mouse myoblasts[4].
In Vivo：Meglumine (Excipient) (25 or 50 mM; 37.5 mM, taken orally dissolved in water) reduces levels of inflammatory factors and inhibits skin cancer tumor growth in rats and mice[2]. Meglumine (Excipient) (18 mM, oral gavage) improves muscle function, limits metabolic syndrome, and reduces diabetic complications in type 2 diabetic mice[4].
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References：
[1]. de Souza ALR, et al. Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110523. [Content Brief]
[2]. Manley K, et al. Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine. J Cell Biochem. 2019 Jul;120(7):12051-12062. [Content Brief]
[4]. Bravo-Nuevo A, et al. Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes. PLoS One. 2014 Feb 27;9(2):e90031. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。