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Lactate (sodium) (60% in water)

MCE China：Lactate (sodium) (60% in water)

Brand：MedChemExpress (MCE)

Cat. No.HY-B2227B

CAS：72-17-3

Synonyms：Lactic acid sodium

Purity：98.0%

Storage：Solution, -20°C, 2 years

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Lactate (60% in water) (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate sodium (60% in water) is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium (60% in water) can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium (60% in water) is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium (60% in water) is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection. Lactate sodium (60% in water) also has antimicrobial activity, which can be used as a food preservative.

In Vitro：Hypertonic Lactate sodium solution improved cognitive function in rats with traumatic brain injury (TBI). Hyperlactate sodium solution also decreased intracranial pressure (ICP) and increased cerebral blood flow by arteriole dilation[2][3].Lactate sodium inhibits the proliferation of various decrepit microorganisms, including aerobic and chillophilic bacteria, pseudomonas, lactic acid bacteria and Enterobacteriaceae[6].

In Vivo：The pH of the working solution needs to be adjusted to around 7.4 before administration to animals.

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References：

[1]. Brooks GA. Lactate: link between glycolytic and oxidative metabolism. Sports Med. 2007;37(4-5):341-3.  [Content Brief]

[2]. Ichai C, et al. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Med. 2009 Mar;35(3):471-9.  [Content Brief]

[3]. Rice AC, et al. Lactate administration attenuates cognitive deficits following traumatic brain injury. Brain Res. 2002 Feb 22;928(1-2):156-9.  [Content Brief]

[4]. Hospira, Inc. (November 2004). "Sodium Lactate (sodium lactate) Injection, Solution, Concentrate". DailyMed. U.S. National Library of Medicine. Archived from the original on 2014-01-04. Retrieved 2012-08-16.

[5]. Forsythe SM, et al. Sodium bicarbonate for the treatment of lactic acidosis. Chest. 2000 Jan;117(1):260-7.   [Content Brief]

[6]. Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18(5):566-575.  [Content Brief]