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Iloprost

MCE China：Iloprost

Brand：MedChemExpress (MCE)

Cat. No.HY-A0096

CAS：78919-13-8

Synonyms：Ciloprost; ZK 36374

Purity：99.76%

Storage：Pure form -20°C 3 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research.

In Vitro：Prostacyclin (PGI2) is synthesised in oviductal fluid and enhance the embryo development[1]. Iloprost is an PGI2 analog, and affects maturation and developmental competence of bovine oocytes[1]. Iloprost (0.5 μM; 22-24 h) increases blastocyst rates of bovine embryos as well as proportion of expanded blastocysts[1]. Iloprost (0.5 μM; 22-24 h) assists maturation rates and cumulus cell expansion of bovine oocytes, and increases the mRNA expression of genes related to cumulus expansion[1]. Iloprost (0.5 μM; 22-24 h) reduces the occurrence of apoptosis in COCs and promotes an anti-apoptotic balance in the transcription of genes involved in apoptosis (BAX and BCL2) [1].

In Vivo：Iloprost (0.3 mg/kg/min; via s.c. mini pumps; 33 d) has a significant anti-metastatic activity in a spontaneously metastasizing tumor model in rat[2]. Iloprost (0.2 mg/kg/d; i.p.; 10 d) attenuates hyperoxia effects and reduces inflammation in the newborn mouse lung, with Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment[3]. Iloprost (0.2 mg/kg; i.v. or i.p.) exhibits short half-life, and is often administered by means of frequent (every 2-4h) inhalation in treatment[4]. Comparison of pharmacokinetic parameter in rats and mice[4] Animal Route Dose (mg/kg) AUC (ng•h/mL) F (%) CL (range) (mL/min/kg) t1/2λi (min) t1/2λz (min) Mice i.v. 0.2 21.9 100 152 3 15 Rat i.g. 0.2 2.2 10 / 4 58

IC50 & Target：IP

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References：

[1]. Kowalczyk-Zieba I, et al. Iloprost affects in vitro maturation and developmental competence of bovine oocytes. Theriogenology. 2020 Nov;157:286-296.  [Content Brief]

[2]. Hildebrand M. Pharmacokinetics of iloprost and cicaprost in mice. Prostaglandins. 1992 Nov;44(5):431-42.  [Content Brief]

[3]. Olave N, et al. Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L535-L544.  [Content Brief]

[4]. Schneider MR, et al. Effects of prostacyclin analogues in in vivo tumor models. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:901-8.  [Content Brief]