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MedChemExpress - Model Musk ketone - ...

MedChemExpress - Model Musk ketone -81-14-1

Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis[1][2][3].

Musk ketone

MCE China：Musk ketone

Brand：MedChemExpress (MCE)

Cat. No.HY-N2045

CAS：81-14-1

Purity：99.41%

Storage：-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis.

In Vitro：Musk ketone (0.9 and 1.8 μM) enhances proliferation and differentiation in neural stem cells (NSCs), along with increased PI3K/Akt signaling pathway activation[3]. Musk ketone (0-100 μM, 48 h) inhibits the cell viability of GC cells, with IC50s of 4.2 µM for AGS cells and 10.06 µM for HGC-27 cells, and inhibits colonies formation[5]. Musk ketone (4.2 µM for AGS, 10.06 µM for HGC-27; 48 h) induces cell cycle arrest and apoptosis in AGS and HGC-27 cells[5].

In Vivo：Musk ketone (0.5 and 1 mg/kg, i.p.) ameliorates neurological deficit and reduces infarction and cerebral ischemic injury induced by middle cerebral artery occlusion (MCAO) in rats[3]. Musk ketone (20-200 mg/kg, p.o., 7 days) increases CYP2B activity, protein and mRNA levels, and increases CYP1A enzyme activity[4].

References：

[1]. Yamagishi T, et al. Identification of musk xylene and musk ketone in freshwater fish collected from the Tama River, Tokyo. Bull Environ Contam Toxicol. 1981 May;26(5):656-62. [Content Brief]

[2]. Mersch-Sundermann V, et al. Musk ketone enhances benzo(a)pyrene induced mutagenicity in human derived Hep G2 cells. Mutat Res. 2001 Aug 22;495(1-2):89-96. [Content Brief]

[3]. Zhou Z, et al. Musk Ketone Induces Neural Stem Cell Proliferation and Differentiation in Cerebral Ischemia via Activation of the PI3K/Akt Signaling Pathway. Neuroscience. 2020 May 21;435:1-9. [Content Brief]

[4]. Lehman-McKeeman LD, et al. Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes. Toxicol Lett. 1999 Dec 20;111(1-2):105-15. [Content Brief]

[5]. An J, et al. Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2. Mol Med Rep. 2021 Jun;23(6):450. [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
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•   The biological activity of the products has been verified by the experiments of customers in various countries；
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MedChemExpress - Model Musk ketone -81-14-1

MCE products for research use only. We do not sell...

Musk ketone