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MedChemExpress - Model Tea polyphenol -84650-60-2
Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism[1].MCE products for research use only. We do not sell to patients.
Tea polyphenol
MCE China：Tea polyphenol
Brand：MedChemExpress (MCE)
Cat. No.HY-N1925
CAS：84650-60-2
Purity：99.0%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism.
In Vivo：Tea polyphenol (400 mg/(kg∙d) in diet for eight weeks) lowers serum glucose and blood lipids in diabetic cardiomyopathy model rats[1]. Tea polyphenol (400 mg/(kg∙d) in diet) improves spatial cognitive abilities in rats with chronic cerebral hypoperfusion[5]. Tea polyphenol (5-20mg/kg, p.o., for 7days) shows antidepressant-like effects in mice following the forced swimming test (FST) and tail suspension test (TST)[6]. Tea polyphenol (100-400 mg/kg in diet per day) protects mice from Acetaminophen (HY-66005)-induced hepatotoxicity by reducing CYP2E1 and CYP1A2 expression in mice[7].
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References：
[1]. Suzuki J, et al. Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases. Mediators Inflamm. 2009;2009:494928. [Content Brief]
[2]. Chen D, et al. Tea polyphenols, their biological effects and potential molecular targets. Histol Histopathol. 2008 Apr;23(4):487-96. [Content Brief]
[3]. Mao X, et al. Oxidative stress-induced diseases and tea polyphenols. Oncotarget. 2017 Sep 14;8(46):81649-81661. [Content Brief]
[4]. Hui Zhou, et al. Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy. J Zhejiang Univ Sci B. 2018 May;19(5):333-341. [Content Brief]
[5]. Xu Y, et al. Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress. J Nutr Biochem. 2010 Aug;21(8):741-8. [Content Brief]
[6]. Zhu WL, et al. Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacol Res. 2012 Jan;65(1):74-80. [Content Brief]
[7]. Chen X, et al. Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression. World J Gastroenterol. 2009 Apr 21;15(15):1829-35. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。