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Rosavin

MCE China：Rosavin

Brand：MedChemExpress (MCE)

Cat. No.HY-N0507

CAS：84954-92-7

Purity：99.99%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body’s response to environmental stress. Rosavin significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation, also impacts various diseases, demonstrating antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, Rosavin improves survival, reducing intestinal damage in irradiated rats and Ischemia-reperfusion(I/R)-induced cerebral injury in vivo by regulating inflammation and oxidative stress, making it a promising candidate for research in radiation-induced intestinal injury, I/R-induced cerebral injury and osteoporosis.

In Vitro：Rosavin (0-100 μM, 72 h) shows more protective effect on the cell viability at a low concentration in the irradiated intestinal epithelioid cell lines[1].

In Vivo：Rosavin (2 ml, 200 mg/kg, i.g., 7 days) significantly increases survival rate in irradiated rats and improves the intestinal structure and function on radiation-induced intestinal injury[1]. Rosavin (2 ml, 200 mg/kg, i.g., assay at day 1, 3, 5, and 7 day after radiation) significantly reduces the level of TNF-α, IL-1β, neutrophil infiltration and increases the level of IL-10 in irradiated rats, thereby attenuates inflammatory damage caused by radiation. Additionally, Rosavin exerts anti-oxidation property in irradiated rats[1][2]. Rosavin (2.5, 5, 10 mg/kg, infusion, daily for 3 days) protects against Ischemia–reperfusion (I/R)-induced cerebral injury in vivo and attenuates I/R-induced inflammation both in mice and HBMVECs. Additionally, Rosavin exhibits I/R-induced apoptosis in mouse brain tissues and significantly suppresses the activation of the phosphorylation of ERK1/2, p38 and JNK1/2 both in vivo and in vitro[3].

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References：

[1]. Weijie Zhou, et al. The Protective Effect of Rosavin from Rhodiola rosea on Radiation-Induced Intestinal Injury[J]. Chem. Biodiversity. 2020 October 22, 17, e2000652.  [Content Brief]

[2]. Liu QH, et al. Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4/NF-κB/MAPK Singnaling Pathways[J]. Int J Mol Sci. 2024 Feb 3;25(3):1875.  [Content Brief]

[3]. Zou H, et al. Rosavin protects the blood-brain barrier against ischemia/reperfusion-induced cerebral injury by regulating MAPK-mediated MMPs pathway[J]. Clin Exp Pharmacol Physiol. 2023 Aug;50(8):664-676.  [Content Brief]

[4]. Wojdasiewicz P, et al. The Role of Rosavin in the Pathophysiology of Bone Metabolism[J]. Int J Mol Sci. 2024 Feb 9;25(4):2117.  [Content Brief]