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MedChemExpress - Model Pyridoxal 5'-phosphate hydrate -853645-22-4
Pyridoxal 5'-phosphate hydrate is an endogenous metabolite.MCE products for research use only. We do not sell to patients.
Pyridoxal 5'-phosphate hydrate
MCE China：Pyridoxal 5'-phosphate hydrate
Brand：MedChemExpress (MCE)
Cat. No.HY-W011727
CAS：853645-22-4
Synonyms：Pyridoxal phosphate hydrate
Purity：99.76%
Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Pyridoxal 5'-phosphate hydrate is an endogenous metabolite.
In Vitro：Pyridoxal 5'-phosphate hydrate (500 μM, 24 h) activates the ERK/c-Jun signaling pathway, promotes the expression of IGFBP1 protein in HepG2 cells[3]. Pyridoxal 5'-phosphate hydrate (0.5 mg/mL, 48h) inhibits the proliferation of cancer cells SK-OV-3 and OVCAR-3[5].
In Vivo：Pyridoxal 5'-phosphate hydrate (1 mg/kg, ip, single dose) alleviates Aβ25-35-induced spatial memory impairment and long-term memory impairment in mouse models[4]. Pyridoxal 5'-phosphate hydrate (600 mg/kg/day, po for 16 weeks) inhibits the formation of advanced glycation end-products (AGEs), and prevents the progression of diabetic nephropathy in Streptozotocin (HY-13753)-induced rats diabetes model[6].
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References：
[1]. Allen GF, et al. Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states.J Neurochem. 2010 Jul;114(1):87-96. [Content Brief]
[2]. Calderón-Ospina CA, et al. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin.CNS Neurosci Ther. 2020 Jan;26(1):5-13. [Content Brief]
[3]. Zhang P, et al., High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c‑Jun pathway. Mol Med Rep. 2013 Oct;8(4):973-8. [Content Brief]
[4]. Choi JM, et al., Membrane-Free Stem Cells and Pyridoxal 5'-Phosphate Synergistically Enhance Cognitive Function in Alzheimer's Disease Mouse Model. Antioxidants (Basel). 2022 Mar 21;11(3):601. [Content Brief]
[5]. Zhang L, et al., Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer. Cell Death Dis. 2017 Dec 13;8(12):3214. [Content Brief]
[6]. Nakamura S, et al., Pyridoxal phosphate prevents progression of diabetic nephropathy. Nephrol Dial Transplant. 2007 Aug;22(8):2165-74. [Content Brief]
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