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MedChemExpress - Model Thymol - 89-83-8

MedChemExpress - Model Thymol -89-83-8

Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects[1].

Thymol

MCE China：Thymol

Brand：MedChemExpress (MCE)

Cat. No.HY-N6810

CAS：89-83-8

Purity：99.90%

Storage：Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Thymol is a TRPA1 agonist. Thymol induces cancer cell apoptosis. Thymol is the main monoterpene phenol occurring in essential oils isolated from plants belonging to the Lamiaceae family, and other plants such as those belonging to the Verbenaceae, Scrophulariaceae, Ranunculaceae and Apiaceae families. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects.

In Vitro：Thymol (20 μM, 24-48 h) inhibits the IL4I1 expression (24 h), and inhibits aryl hydrocarbon receptor (AHR) signaling (48 h) in A549 cells[2]. Thymol (5 μM, 48 h) inhibits epithelial‐mesenchymal transition and the motility activity in A549 cells[2]. Thymol (0-600 μM, 48 h) inhibits cell proliferation in multiple cancer cell types (Cal27, SCC4, SCC9, HeLa, H460, MDA-231 and PC3 cells)[3]. Thymol (200 μg/mL) induces a caspase-dependent conidial apoptosis in A. flavus[4].

In Vivo：Thymol single (75 mg/kg, i.p.) inhibits the progression of LUAD in an orthotopic mouse lung adenocarcinoma (LUAD) model, and sensitizes the anti‐PD‐1 antibody treatment when in combination with anti‐PD‐1 antibody (10 mg/kg, i.p.)[2]. Thymol (4.3 mM in 50 μL sterile saline, intra-tumor injection, every other day) shows antitumor effects in Cal27-derived xenografts mice[3].

References：

[1]. Marchese A, et al. Antibacterial and antifungal activities of thymol: A brief review of the literature. Food Chem. 2016 Nov 1;210:402-14. [Content Brief]

[2]. Li T, et al. Thymol targeting interleukin 4 induced 1 expression reshapes the immune microenvironment to sensitize the immunotherapy in lung adenocarcinoma. MedComm (2020). 2023 Aug 30;4(5):e355. [Content Brief]

[3]. De La Chapa JJ, et al. Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis. J Oral Pathol Med. 2018 Aug;47(7):674-682. [Content Brief]

[4]. Hu LB, et al. Thymol Induces Conidial Apoptosis in Aspergillus flavus via Stimulating K+ Eruption. J Agric Food Chem. 2018 Aug 15;66(32):8530-8536. [Content Brief]

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MedChemExpress - Model Thymol -89-83-8

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Thymol