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Thyrotropin

MCE China：Thyrotropin

Brand：MedChemExpress (MCE)

Cat. No.HY-107916

CAS：9002-71-5

Synonyms：TSH; Pretiron

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism.

In Vitro：Thyrotropin (rhTSH, 0.1-10 nM, 2-3 weeks) enhances human T-cell development[8]. Thyrotropin (bovine thyrotropin, 100 milliunits per mL, the first 24 to 48 h after trypsinization) develops follicle-like structures in dog, human, and bovine thyroid cells[10]. Thyrotropin (1 nM) promotes proliferation of FRTL-5 cells[11]. Thyrotropin regulates thyroid cell proliferation and differentiation[12]. Thyrotropin (10 mU/mL, up to 72 h) prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells[13].

In Vivo：Thyrotropin (0.1-10 mIU/10 μL, ICV, 4 h after dawn) is involved in photoperiodic signaling and induces thyroid hormone-activating (DIO2) expression in a dose-dependent manner in mice[5]。 Thyrotropin (i.p.) stimulates thyroid hormone into the circulation in wild-type and heterozygous mice[6]. Thyrotropin (rhTSH, 0.1 μg/g, i.p.) more readily replaces endogenous TSH in mice than in rat thyroid TSH receptors[7]. Thyrotropin (0.05 USP unit twice daily, i.p., 6 days) causes an increase in the weight of the thyroid but no increase in body weight in hereditary dwarf mice[9].

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References：

[1]. Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev. 2002 Nov;60(11):374-7.  [Content Brief]

[2]. Vassart G, et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992 Aug;13(3):596-611.  [Content Brief]

[3]. Kim SM, et al. Thyrotropin, Hyperthyroidism, and Bone Mass[J]. J Clin Endocrinol Metab. 2021 Nov 19;106(12):e4809-e4821.  [Content Brief]

[4]. Chandrasekar A, et al. Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes[J]. Thyroid. 2024 Feb;34(2):261-273.  [Content Brief]

[5]. Ono H, et al. Involvement of thyrotropin in photoperiodic signal transduction in mice. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18238-42.  [Content Brief]

[6]. Marians RC, et al. Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15776-81.  [Content Brief]

[7]. Colzani RM, et al. The effect of recombinant human thyrotropin (rhTSH) on thyroid function in mice and rats. Thyroid. 1998 Sep;8(9):797-801.  [Content Brief]

[8]. van der Weerd K, van Hagen PM, Schrijver B, Heuvelmans SJ, Hofland LJ, Swagemakers SM, Bogers AJ, Dik WA, et al. Thyrotropin acts as a T-cell developmental factor in mice and humans. Thyroid. 2014 Jun;24(6):1051-61.  [Content Brief]

[9]. Denef JF, et al. The influence of thyrotropin and growth hormone on the thyroid gland in the hereditary dwarf mouse: a morphometric study. Endocrinology. 1980 Oct;107(4):1249-57.  [Content Brief]

[10]. Winand R J, et al. Thyrotropin effects on thyroid cells in culture. Effects of trypsin on the thyrotropin receptor and on thyrotropin-mediated cyclic 3': 5'-AMP changes. Journal of Biological Chemistry, 1975, 250(16): 6534-6540.

[11]. Medina DL, et al. Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems. Eur J Endocrinol. 2000 Aug;143(2):161-78.  [Content Brief]

[12]. Dumont JE, et al. Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev. 1992 Jul;72(3):667-97.  [Content Brief]

[13]. Li X, et al. Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells. Endocrinology. 1999 Dec;140(12):5962-70.  [Content Brief]