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MedChemExpress - Model Polyethylene glycol mono(4-tert-octylphenyl) ether - 9002-93-1
Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is a nonionic surfactant[1][2].MCE products for research use only. We do not sell to patients.
Polyethylene glycol mono(4-tert-octylphenyl) ether
MCE China:Polyethylene glycol mono(4-tert-octylphenyl) ether
Brand:MedChemExpress (MCE)
Cat. No.HY-Y1883A
CAS:9002-93-1
Purity:99.8%
Storage:Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is a nonionic surfactant.
In Vitro:Polyethylene?glycol?mono(4-tert-octylphenyl)?ether (0.5%-0.05%, 1 h) reduces the infectivity of a classical enveloped virus such as West Nile virus (WNV)[3]. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether (0.19-0.20 mM) makes the HeLa cells underwent irreversible permeabilization of the membrane and structural collapse[4]. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether (0.01%, 1 h) induces apoptotic and necrotic death in prostate and colon cancer cell lines (PC-3, SW-620 and HT-29 cells), characterized by the typical morphological features and internucleosomal DNA fragmentation[5].
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References:
[1]. Colavita F, et al. J Clin Virol. 2017 Jan;86:27-30. [Content Brief]
[2]. Herman SM, et al. J Allergy Clin Immunol Pract. 2021;9(7):2941. [Content Brief]
[3]. Koley D, et al. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16783-7. [Content Brief]
[4]. Ghosh R, et al. Int J Biol Macromol. 2021;167:736-745. [Content Brief]
[5]. Borner MM, et alE. FEBS Lett. 1994 Oct 17;353(2):129-32. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
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• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
