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MedChemExpressModel Polyethylene glycol mono(4-tert-octylphenyl) ether - 9002-93-1

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Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is a nonionic surfactant[1][2].
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Polyethylene glycol mono(4-tert-octylphenyl) ether

MCE China:Polyethylene glycol mono(4-tert-octylphenyl) ether

Brand:MedChemExpress (MCE)

Cat. No.HY-Y1883A

CAS:9002-93-1

Purity:99.8%

Storage:Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether is a nonionic surfactant.

In Vitro:Polyethylene?glycol?mono(4-tert-octylphenyl)?ether (0.5%-0.05%, 1 h) reduces the infectivity of a classical enveloped virus such as West Nile virus (WNV)[3]. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether (0.19-0.20 mM) makes the HeLa cells underwent irreversible permeabilization of the membrane and structural collapse[4]. Polyethylene?glycol?mono(4-tert-octylphenyl)?ether (0.01%, 1 h) induces apoptotic and necrotic death in prostate and colon cancer cell lines (PC-3, SW-620 and HT-29 cells), characterized by the typical morphological features and internucleosomal DNA fragmentation[5].

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References:

[1]. Colavita F, et al. J Clin Virol. 2017 Jan;86:27-30.  [Content Brief]

[2]. Herman SM, et al. J Allergy Clin Immunol Pract. 2021;9(7):2941.  [Content Brief]

[3]. Koley D, et al. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16783-7.  [Content Brief]

[4]. Ghosh R, et al. Int J Biol Macromol. 2021;167:736-745.  [Content Brief]

[5]. Borner MM, et alE. FEBS Lett. 1994 Oct 17;353(2):129-32.  [Content Brief]

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