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MedChemExpress - Model Phenothiazine -92-84-2
Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases[1][2].MCE products for research use only. We do not sell to patients.
Phenothiazine
MCE China：Phenothiazine
Brand：MedChemExpress (MCE)
Cat. No.HY-Y0055
CAS：92-84-2
Synonyms：Thiodiphenylamine
Purity：99.90%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases.
In Vitro：Phenothiazine inhibits cell death caused by oxidative stress in cells HT22 (causes by glutamate, EC50=0.02 μM), SK-N-MC (causes by H2O2, EC50=0.02 μM)and SH-SY5Y (causes by MPP+, EC50=0.02 μM). Phenothiazine inhibits lipid peroxidation in Ascorbate (HY-B0166)-damaged pig brain membranes, exhibits antioxidant efficacy[3].
In Vivo：Phenothiazine causes acute hemolytic anemia, exhibits neurotoxicity and phototoxicity in pigs and horses[2]. Phenothiazine protects dopaminergic neurons from the toxic effects of MPP+ and Rotenone (HY-B1756) in C. elegans models[3]. Phenothiazine (5-30 mg/kg, sc, single dose) reduces brain lesions, and exhibits neuroprotective efficacy in traumatic brain injury (TBI) mouse models[4].
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References：
[1]. Jun-hua Xiao, et al. Xiao JH, Zhang YL, Ding LL, Feng XL, Wang JL. Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine. Yao Xue Xue Bao. 2005 Feb;40(2):105-10. [Content Brief]
[2]. Mitchell SC, et, al. The toxicity of phenothiazine. Drug Metabol Drug Interact. 1994;11(3):201-35. [Content Brief]
[4]. Songarj P, et al., The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice. Neurosci Lett. 2015 Jan 1;584:253-8. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。