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MedChemExpressModel DUB-IN-3 -924296-17-3

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DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme USP8 with an IC50 value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease[1].
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DUB-IN-3

MCE China:DUB-IN-3

Brand:MedChemExpress (MCE)

Cat. No.HY-50737

CAS:924296-17-3

Purity:98.41%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping:Room temperature in continental US; may vary elsewhere.

Description:DUB-IN-3 (compound 22c) is a potent and selective inhibitor of the deubiquitinating enzyme USP8 with an IC50 value of 0.56 μM. DUB-IN-3 is promising for research of cancer, neurodegenerative diseases, inflammation, viral infection and cardiovascular disease.

In Vitro:DUB-IN-3 (10 nM-100 μM) affects the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50 values of 0.5-1.5 μM range[1]. Inhibitory effect of DUB-IN-3 on USP7 and USP8 deubiquitinating activity (IC50: μM)[1] Compd USP7 USP8 DUB-IN-3 >100 0.56

IC50 & Target:USP7 >100 μM (IC50)

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References:

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.  [Content Brief]

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