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Athens - Model 16-16-012901 -Alpha 2 Antiplasmin, Human Plasma
Alpha 2 Antiplasmin, Human Plasma (Coagulation Factor). Efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots. Found in plasma at about 70 ug per ml. Alpha-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging.
MW: 70,000
Extinction Coefficient: 0.703
Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl.
Storage:
Purity: >=95% by SDS-PAGE
Activity: >= 5.0 U/mg
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.
Product Citation:
Zimmerman, Thomas P., Valery Novokhatny, Shan Jiang, and James D. Colandene. "Reversibly inactivated acidified plasmin composition." U.S. Patent Application 13/761,684, filed February 7, 2013.
Singh S, Houng A, Reed GL.
Releasing the Brakes on the Fibrinolytic System in Pulmonary Emboli.
Circulation. 2017 Mar 14;135(11):1011-1020. doi: 0.1161/CIRCULATIONAHA.116.024421. Epub 2016 Dec 27