Antibodies for Immune Cell Therapy

There are several ways to harness the power of the immune system for cellular immunotherapy:

• Harvest and expand tumor infiltrating lymphocytes (TILs), endogenous T cells and Natural Killer (NK) cells in the tumor microenvironment (TME).
• Genetically engineer T cells with a unique tumor-antigen specific TCR.
• Knockout inhibitory receptors like PD-1, CTLA-4 or NKG2A in isolated T cells or NK cells.
• Insert chimeric antigen receptors (CAR)s, which include an antigen-recognition domain linked directly to a costimulatory domain, into T cells or NK cells.
  • CAR T cells bypass the requirement for antigen presentation by MHC I.
  • CAR NK cells impart antigen specificity to these potently cytotoxic cells.

Antibodies are critical tools for each step of the cellular immunotherapy workflow. They can be used to isolate, activate, and characterize both the cellular input and the final immune cell therapy product. Whether your goal is to isolate and expand TILs or engineer CAR T cells or CAR NK cells, Bio-Techne has validated antibodies and other quality reagents for each stage of the manufacturing process. Learn more about how Bio-Techne reagents and instruments can streamline and enhance your T cell manufacturing or NK cell therapy workflow.

• Take your immune cell therapy to the clinic with our custom GMP antibodies for ex vivo use.
• Develop an antibody from scratch to your exact specifications.
• Convert an existing research-grade antibody into a recombinant GMP antibody.