Brolis - Blood Analysis Sensor

• A small portable swept-wavelength laser shines into tissue with capillary network and interacts with target molecules that have resonant absorption.
• The reflected light carrying molecule species and concentration information is collected back in a sensor-on-chip and a real-time signal analysis is carried out.
• Sensing is performed in a fraction of a second, which means the sensor system-on-chip offers real-time measurements.

• Brolis’ integrated sensor is able to cover a wavelength range of over 500 nm in a fraction of a second. 
• We measure the full shape of the absorption spectrum and not just several points. 
• It is real-time. The Brolis system’s tuning speed allows us to record thousands of spectra in a second, which makes achieving real-time data possible.

We present a new technological solution that will lift blood analysis to a higher level, making it easily accessible to everyone.

• Coverage of unique spectral region between 1.7 to 2.5 micrometersHere, in contrast to shorter-wavelength range, strong overtone and combination absorption bands of desired molecules exist. Moreover, water has a local absorption minimum in this spectral region, what allows extracting molecule specie and concentration data.
• Laser-based absorption spectroscopyMolecules in liquid media have broad absorption spectral bands that span hundreds of nanometers. The shape of this broad signal carries information about the species and concentration, and acts as a fingerprint.
• Integrated ultra-widely swept laser sourcesIn order to use full spectral information, we developed unique integrated ultra-widely swept laser sources. They are based on our proprietary know-how of GaSb materials and silicon photonics.
  We use an ultra-narrow single-mode laser line (SMSR > 40 dB) that we sweep across the entire spectral range and take advantage of the highest possible spectral power density and signal-to-noise ratio that the laws of physics allow.
  Finally, our sensor approach requires the lowest amount of discrete III-V components possible, making it the most efficient solution in terms of footprint and functionality.

To tackle the sensor problem, we created a technology that did not exist before. We build everything ourselves – from exotic GaSb (Gallium Antimonide) based material synthesis, to the world’s first ultra-widely swept hybrid GaSb-Si Photonics integrated laser.

The latter allowed us to create the world’s first laser-based sensors realized in a silicon photonics chip that is smaller than 5 sq. mm. All this know-how is proprietary to Brolis and was developed purely in-house.

Brolis Sensor is

• Accessible It can be used at any point of care
• Portable It does not require special premises to operate in
• Time saving It measures blood in real-time
• User-friendlyIt does not require the expertise of laboratory technicians
• AffordableLow-cost hardware

Transdermal Sensor Performance.

• Determination coefficient R² =
• 0.98 glucose / 0.92 lactate / 0.96 ethanol
• RMSEP = 0.7 mM glucose / 0.924 mM lactate / 0.2 permil ethanol
• MARD = 5.7% glucose  / lactate, ethanol not relevant
• > 97% of data points within area A for glucose (clinically reliable)