CAR-Macrophages (CAR-M)

Macrophages are versatile cells. They exhibit abilities to survive solid tumor microenvironment, to trigger inflammation and to absorb and digest debris or infected cells. CAR-Macrophages (CAR-M) are artificially directed against a cancerous target by a chimeric antigen receptor. CAR-M are still in their clinical infancy, however specific abilities of macrophages make them a promising approach to treat solid tumors resisting to available therapies. We are currently in the early-stage development of CAR-M with our miniaturization and optimization technologies.