InnoSer Belgie NV

InnoSerModel P10 -In Vivo ADPKD Mouse Model for Polycystic Kidney Disease

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Quick progression of cyst formation in the distal segment of the nephron

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InnoSer offers different ADPKD mouse models by specifically timed Tamoxifen-induced Pkd1 knockout. There are three models available depending on which post-natal (P) day Tamoxifen is administered: 

The P10 model is widely used as a first screening platform as it offers quick and robust results with renal cyst formation, while the P18 and P40 models show a slower progression even closer to clinical phenotypes. 

For all your nephrology projects, we support custom in vivo models for kidney injury and toxicological studies. 

  • Body weight (monitored daily)
  • Kidney weight
  • Kidney weight to body weight ratio
  • Urea measurement
  • Histopathology: cystic index and pathological lesions
  • Ultrasound imaging to determine kidney volume

  • Multiple well established models
  • AAALAC accredited facilities
  • Organ and blood sampling for additional tailored analysis