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Stemline Hematologic Equipment & Supplies
3 equipment items found
by:Stemline Therapeutics, Inc. based inNew York, NEW YORK (USA)
SL-801 is a structurally novel, oral, small molecule, reversible inhibitor of exportin-1 (XPO1), a nuclear transport protein implicated in both solid tumors and hematologic malignancies. SL-801 has demonstrated preclinical in vitro and in vivo antitumor activity against a wide array of solid and hematologic cancers. SL-801’s potential ability to reversibly ...
by:Stemline Therapeutics, Inc. based inNew York, NEW YORK (USA)
In addition to expression on tumor bulk, CD123 expression has been reported on the cancer stem cells (CSCs), of certain hematologic cancers including AML, CML, MDS, and potentially T-cell ALL. In addition, elevated CD123 expression has been correlated with poor prognosis in certain hematologic ...
by:Stemline Therapeutics, Inc. based inNew York, NEW YORK (USA)
Inhibition of XPO1 has been shown to restore tumor suppressor function and proper cell cycle regulation, leading to apoptosis of cancer cells. XPO1 has also been shown to be a clinically validated target in both solid and hematological cancers. SL-801 has demonstrated broad and SL-801 has demonstrated broad and potent preclinical activity in a wide array of solid and ...