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Acuitas Mrna Equipment & Supplies
3 equipment items found
Manufactured by:Acuitas Therapeutics based inVancouver, BRITISH COLUMBIA (CANADA)
Proteins are the “workhorses” within cells responsible for metabolic processes, transport processes and structural elements. They are coded by genes on DNA and this code is transcribed into a message (messenger RNA or mRNA) within the cell nucleus. This mRNA then leaves the nucleus and is translated into the protein on ribosomes (Figure 1). ...
Manufactured by:Acuitas Therapeutics based inVancouver, BRITISH COLUMBIA (CANADA)
This evaluation characterizes the potency and safety of these LNP carriers for delivery of nucleic acid payloads including siRNA, mRNA, plasmid and antisense oligonucleotides. We have shown that the ionizable cationic lipid component critically determines the potency of LNP therapeutics. ...
Manufactured by:Acuitas Therapeutics based inVancouver, BRITISH COLUMBIA (CANADA)
Acuitas scientists, in collaboration with other researchers, have established the mechanism whereby certain LNP carriers can provide highly efficient delivery to hepatocytes in the liver (Akinc et al., Mol Ther. 2010). After intravenous administration, the PEG-lipid component that shields the surface of our LNP exchanges off. This allows binding of the plasma protein ApoE to the exposed neutral ...