Flow CAST - Kinase Inhibition Assays

Targeting Immune Cell Signaling Pathway in Oncology
Phosphatidylinositol 3-kinase (PI3K) and Bruton’s tyrosine kinase (BTK) play an integral role in a number of cellular functions which ultimately lead to survival and growth of normal cells. Aberrant activation of this pathway promotes carcinogenesis and tumor angiogenesis. Research has shown that ~1/3 of human cancers develop as a result of aberrant PI3K signaling. Inhibitors of the PI3K/BTK pathway are a large focus for several different pharmaceutical companies with >10 small-molecule PI3K inhibitors currently at different stages of development.