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Cellomics - Model sgRNA CRISPR/Cas9 -GT-10006-50 -Lentiviral Cish
CISH (Cytokine Inducible SH2 Containing Protein) contains a SH2 domain and a SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CISH may be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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This lentivirus expresses human CISH sgRNA under the control of the U6 promoter, Cas9 nuclease and puromycin under the control of the EF1a promoter.
Virus: Lentiviral CISH sgRNA CRISPR/Cas9
- Titer (approx): 1 x 107 TU/ml
- Vector Information: Vector includes both 5’ and 3’ lentiviral LTR and all necessary elements for effective transduction; woodchuck hepatitis virus posttranscriptional regulatory element (WPRE)
- Promoter for sgRNA: U6
- Promoter for Cas9 nuclease: Ef1a
- Species:
- Human
- sgRNA target gene: CISH
- sgRNA Sequence:
- C CAT GAT GAT GAC ACA GCC A
- Selection Gene: Puromycin
- Biosafety Level: BSL-2
- Shipped: Dry ice
- Storage: Store at -80°C