Mantarray - 3D Tissue Contractility Analysis
Mantarray is Curi’s Platform for Human-Relevant 3D Engineered Muscle Tissue Analysis. Get Clinically-relevant Functional Data with 3D Tissues. Mantarray brings functional data into the earliest stages of preclinical testing of new medicines. By providing parallel analysis of 3D engineered muscle tissues with adult-like functional profiles, Mantarray enables the discovery, safety, and efficacy testing of new therapeutics.
- Contractile Force
- Force Frequency
- Rate of Contraction/Systole
- Rate of Relaxation/Diastole
- Time to Max Twitch (Peak)
- Maximal Twitch Amplitude
- Full Width at Half Max
Easily Form 3D Tissues in Your Lab
With over 95% tissue formation success rate, the Mantarray Plate Kit allows for reliable and reproducible engineered tissues across 24 wells.
Request a Quote to inquire about getting Mantarray Plate Kits.
- The Mantarray platform provides an easy-to-use, scalable, and flexible system that allows researchers to examine 3D tissues in vitro in the convenience of their own lab.
- Be among the first to receive the instrument. Contact us to inquire about getting a Mantarray Instrument in your lab.
The Mantarray system features a novel magnetic sensing technique that can detect the contraction of EMTs. This enables the user to measure the contractility of 24 tissues in parallel, a high throughput, and in real time. The system features user-friendly software that takes away the requirement for manual calculations of contractility, delivering contractility data at the click of a mouse.
The Mantarray system uses ANSI/SLAS compliant tissue casting devices that can be performed manually or via automation. EMTs can be used in nearly any kind of assay, including force (contractility), calcium, and structural assays. Mantarray brings EMTs into your own lab, allowing you to use your own cells to achieve your research goals.
- High-throughput compatible, label-free, non-optical measurement
- Clinically-relevant functional measurements of contractility
- Easy tissue casting, measurement, and data analysis (No Matlab, All GUI)
- Structurally and functionally mature 3D engineered muscle tissues
- Compatible with electrical stimulation for advanced tissue maturation
- Simultaneous analysis of data from all 24 wells using custom data package
- Easily accessible user reports showing clinically relevant functional data
Complex diseases require complex models. EMTs can be made from cells sourced from patients and used to test whether a new therapy will improve or recover healthy contraction. 3D Engineered Heart Tissues (EHTs) can be generated from human iPSC-derived cells with healthy and diseased phenotypes.
Isogenic controls or corrected cell lines can be used to provide clear stratification between healthy and diseased phenotypes. Stratifying differences between healthy disease model EHTs provides a platform for discovery and validation of new therapeutics. Validate new therapies using human models of muscle contractility.