Narcolepsy Treatment Medicine

WAKIX^® (pitolisant) is a narcolepsy treatment that Citrine has in-licensed from the French biotech company, Bioprojet, for use in China. Pitolisant is a selective histamine H3-receptor antagonist/inverse agonist, which increases the release of the brain chemical histamine to increase a patient`s wakefulness and alertness. The drug was approved by the European Medicines Agency (EMA) in 2016 for the treatment of narcolepsy in adults with or with0out cataplexy and is marketed in major countries in Europe. It was approved by the FDA in 2018 to treat adults suffering from narcolepsy, a serious, chronic disorder characterized by excessive daytime sleepiness (EDS), with or without cataplexy.