SeQureDx - Personalized Diagnostics for Gene Editing Therapies

GUIDE-seq and ONE-seq are used to nominate potential off-target editing sites in cellular models and free DNA, respectively.  ONE-seq has the advantages that it can be used to assess adenine and cytosine base editors, it allows variant-aware analysis of multiple genomes simultaneously (thousands), and it detects a broader spectrum of off-target sites. Target cells or tissues are then tested to confirm which of the nominated sites are altered after therapeutic gene editing.