PIMS Technology

PIMS is able to study protein-protein and protein-solvent interactions in multicomponent solutions. It is used to decipher responder from non-responder subjects or patients. PIMS can quickly identify the response of a tissue or cell when an exogenous molecule is administrated. It therefore reflects patients’ molecular capacity to respond to the drug’s effect and allows different subpopulations within a group to be identified in response to specific treatment.

In other words, it determines an individual fingerprint and response to a therapy.

PIMS analyses the Differential Molecular Oscillation* (DMO) and Relative Dynamic Diffraction (RDD) of a tissue in the presence of the drug candidate being tested.

This technique is used in the early stages of drug development, as well as in patient stratification.

Drug developers benefit from PIMS by being able to identify the patient group on which the compound will have a positive effect. Depending on how patients respond to different treatments on the market, PIMS can safely and accurately determine the best therapy for them. PIMS offers significant opportunities in the field of personalized medicine and biomarkers.

Differential Molecular Oscillation (DMO) is the difference in molecular resonance as a function of time and surrounding environment in the presence of an exogenous molecule as compared to the blank. Relative Dynamic Diffraction (RDD) depends on surrounding water molecules in the presence of an exogenous molecule compared to a blank.