PROZINC - Protamine Zinc Recombinant Human Iinsulin

Following regulation, PROZINC^® (protamine zinc recombinant human insulin) works to safely maintain glycemic control with once-daily dosing in most dogs.

PROZINC is backed by the largest US canine insulin study to date, including over 200 diabetic patients:

Results demonstrated efficacy and control of clinical signs associated with diabetes mellitus in both naive and previously treated diabetic dogs

• 88% of dogs showed improvement in excessive thirst
• 90% of dogs showed improvement in excessive urination
• 72% of dogs achieved diabetic control

PROZINC insulin is used with U-40 syringes, which are specifically calibrated for use with dogs to deliver precise, accurate doses, reducing the risk of under- or overdosing.

Available in two presentations: 10 mL and 20 mL vials (40 IU/mL).

PROZINC^® (protamine zinc recombinant human insulin) should only be administered to the dog for which it was prescribed, and at the dosage and frequency for which it was prescribed. PROZINC requires refrigeration, as well as the use of U-40 syringes, which are sold separately.

It is recommended that PROZINC be administered once daily. However, some dogs require twice-daily dosing 12 hours apart.

USE OF A SYRINGE OTHER THAN A U-40 SYRINGE WILL RESULT IN INCORRECT DOSING.

FOR SUBCUTANEOUS INJECTION ONLY. DO NOT SHAKE OR AGITATE THE VIAL.

PROZINC should be mixed by gently rolling the vial prior to withdrawing each dose from the vial. Once mixed, PROZINC suspension has a white, cloudy appearance. Clumps or visible white particles can form in insulin suspensions: do not use the product if clumps or visible white particles persist after gently rolling the vial.

Using a U-40 insulin syringe, the injection should be administered subcutaneously on the back of the neck or on the side of the dog. Always provide the Client Information Sheet with each prescription.

Starting dose: The recommended starting dose for PROZINC is 0.2-0.5 IU insulin/pound of body weight (0.5-1.0 IU/kg) once daily. The recommended starting dose for naïve dogs is the lower end of the dose range. The recommended starting dose for dogs with poorly controlled diabetes mellitus and transitioning from another insulin product is the mid to higher end of the dose range based on the veterinarian’s experience with the dog’s medical history and previous insulin dose. When transitioning from another insulin, the dog’s blood glucose and general condition should be closely monitored. When transitioning from another insulin, PROZINC should be started once daily, regardless of the frequency of prior insulin use.

The dose should be given concurrently with or right after a meal. The veterinarian should re-evaluate the dog at appropriate intervals and adjust the dose and frequency based on both clinical signs and laboratory test results until adequate glycemic control has been attained. 

Changing to twice-daily dosing: Twice-daily dosing should be considered if the duration of insulin action is determined to be inadequate with once-daily dosing. Use caution when adjusting from once-daily to twice-daily dosing. If twice-daily dosing is initiated, the two doses should each be approximately 25% less than the once-daily dose required to attain an acceptable glucose nadir. 

Further adjustments in the dosage may be necessary with changes in the dog’s diet, body weight, or concomitant medication, or if the dog develops concurrent infection, inflammation, neoplasia, or an additional endocrine or other medical disorder