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Codex - Model HiCap -RNA Polymerase
Achieve exceptional IVT results with Codex® HiCap RNA Polymerase, a co-transcriptional capping RNA polymerase that has been uniquely engineered to produce synthetic mRNA at high yield and low immunogenicity.
Specifically designed to improve capping efficiency over current methods while reducing cap analog requirements, the Codex® HiCap RNA Polymerase increases yields of fully capped mRNA without compromising the total RNA yield.
Reduce the negative immune responses from your vaccine and therapeutic candidates with Codex® HiCap RNA Polymerase, which produces significantly less double-stranded RNA (dsRNA) compared to wild-type T7 RNA polymerase.
Codex® HiCap RNA Polymerase incorporates commonly used uracil analogs to replace canonical uracil (which can also elicit an unintended immune response) during IVT and is able to incorporate a range of commercial uracil analogs.
You can tailor Codex® HiCap RNA Polymerase purchase quantities, concentrations and fill-volumes to meet your demands and integrate seamlessly into your IVT production process. To learn more, please contact us, or visit the Scale-up and Supply page.
Three life science enzymes are currently available for commercial use: a thermostable reverse transcriptase for one-step RT-qPCR assays, a high-fidelity DNA polymerase for next-generation sequencing, and an RNA polymerase with significantly improved co-transcriptional capping.
Reverse transcription at 70 °C
Codex®?HiTemp Reverse Transcriptase is a highly sensitive enzyme engineered for thermostability at temperatures as high as 70 °C. In addition, it is stable at ambient temperature and automation-friendly, making it ideal for custom one-step RT-qPCR assays.
High-fidelity results for NGS
Codex® HiFi Hot Start DNA Polymerase delivers high-fidelity results when applications demand exceptionally accurate DNA sequences. Our enzyme produces 2.5 times more accurate results than the current market-leading, high-fidelity DNA polymerase.