Lena Biosciences, Inc.
- Home
- Companies
- Lena Biosciences, Inc.
- Products
- Lena Biosciences - Synthetic Hemoglobin ...
Lena Biosciences - Synthetic Hemoglobin Blood Substitute
n vivo, over 98% of oxygen delivery to tissues and cells is delivered by hemoglobin contained in the red blood cells. Lena Biosciences Blood Substitute is the first, screening compliant product that solves the problem of poor cellular oxygenation leading to ischemia, necrosis, de-differentiation, and transcriptional drift that cells experience in vitro. Learn how our synthetic hemoglobin analog that mimics erythrocyte function results in superior delivery of respiratory gases to cells, better pH control, and preserved cell functions.
Most popular related searches
red blood cell
hemoglobin
ischemia necrosis
drug metabolism
metabolic enzymes
blood cell
metabolism activity
metabolic activators
metabolic activities
metabolic activation
Blood Substitute provides in vivo-like oxygen delivery to tissues based on cellular demands mimicking the oxygen-hemoglobin dissociation curve. The dissociation of oxygen from hemoglobin is governed by the partial pressure of oxygen in tissues in vivo. The lower the partial pressure of oxygen inside the tissue, the more oxygen dissociates from hemoglobin to meet the tissue demand for oxygen. Highly active tissues have high demands for oxygen. In these tissues, the partial pressure of oxygen is lower allowing more oxygen to dissociate from hemoglobin compared to metabolically less active tissues such as fat which need less oxygen. Our synthetic hemoglobin, Blood Substitute, mirrors these effects for microphysiological systems in vitro raising your research to new heights.
Advantages over air-liquid interface cultures:
- Adaptive oxygen delivery that quickly responds to cellular needs
- Does not result in suprahysiological oxygen tension (~20%) that can contribute to ROS damage when modeling organs that are not directly exposed to air
Advantages for microphysiological systems (MPS):
- Artificial blood for Perfused Organ Panel MPS
- Aseptic perfusion of 48 statistically independent, 3D organ cultures in parallel (in PerfusionPal) using just one tube
- Passively dissolves all respiratory gases
- Mimics the function of erythrocytes
- Provides superior oxygenation to cell cultures
- Maintains stable pH
- Significantly increases the activity of drug metabolizing enzymes
- Twice as dense as water
- Pure and completely inert
- Insoluble in media, reagents, and drugs
- Immiscible with media, reagents and drugs