Viscover - Model Imaging Agents -The First Contrast Agent Portfolio for Small Animal Imaging in All Modalities

Viscover™ provides you with the first dedicated product portfolio of animal contrast agents to unleash the full potential of pre-clinical animal MRI, employing innovative agents from small molecules to nanoparticles. Our GadoSpin™ gadolinium chelate and FeraSpin™ iron oxide nanoparticle product families were designed to offer you previously unseen capabilities.

Specifically, their broad spectrum includes:

• tumor vascularization and angiogenesis studies
• Cardiovascular disease imaging
• Delineation of tissues and organ-specific imaging
• Magnetic resonance angiography (MRA)
• Therapeutic effiacy monitoring
• Nanoparticle physiology
• MRI physics and sequence optimization

Viscover™ brings to you the broadest portfolio of imaging agents tailored for pre-clinical micro-CT. ExiTron™ contrast agents have been specifically developed to provide micro-CT with long sought-after soft-tissue contrast. Novel nanomaterials help extend the application range of any micro-CT far beyond mere bone scans.

A unique portfolio to meet the demands of CT imaging

Our innovative ExiTron™ agents enable targeted high-resolution imaging of tumors and organs with ease.

• ExiTron nano is the only inorganic nanoparticular CT contrast agent allowing blood pool (angiography) and organ-specific (liver, spleen) imaging in a single application
• ExiTron P is a long-circulating polymeric agent for high-resolution CT angiography (CTA)
• ExiTron V is a classical dimeric non-ionic extracellular CT contrast agent for CT angiography (CTA)
• ExiTron U is a classical monomeric non-ionic extracellular CT contrast agent for CT angiography (CTA)

Viscover PolySon™ H/L ultrasound agents are unique hardshell ultrasound microbubbles with ideal physiological and contrast properties for all typical ultrasound methods.

Highly echogenic single particle sensitivity for detailed imaging

PolySon™ agents are micrometer-sized air-filled polymeric particles, or microbubbles. Comprised of a stabile inert organic polymer, they enable reliable in vivo single bubble quantitation via "bubble-destructive" methods, even at high frequencies.

Developed for demanding pre-clinical applications:

• PolySon L is a hardshell ultrasound microbubble agent, optimal for organ perfusion measurements and the visualization of liver and spleen
• PolySon H offers you the same capabilites as PolySon L, but is optimized for measurements at the body surface with high acoustic pressures

NiraWave™ optical contrast agents are novel dyes and nanomaterials ideal for the study of vascular fine structure and disease-related vascular changes.

Visualize blood vessels with exceptional detail

NiraWave™ agents are designed to capitalize the most from your imaging device.

• NiraWave C is the animal imaging formulation of the clinical indocyanine green agent that has been used for angiography (eye), organ perfusion, rheumatology diagnostics and photodynamic therapy research
• NiraWave M is a unique micellar formulation of NiraWave C with a long circulation time ideal for optical angiography and the study of vascular leakage in inflammation and tumors
• NiraWave nano 780 is a nanoparticulate optical imaging agent that provides a broad excitation range, a high quantum yield, and the best possible tissue penetration