Companies
Alfa Chemistry
Services
Alfa Chemistry - Active Pharmaceutical ...

Alfa Chemistry - Active Pharmaceutical Ingredients - Sulfamethoxazole

Sulfamethoxazole, a sulfanilamide, is a structural analog of para-aminobenzoic acid (PABA). It competes with PABA to bind to dihydropteroate synthetase and inhibits the conversion of PABA to dihydrofolic acid. Inhibition of this pathway ultimately prevents the synthesis of folate that is a critical role during DNA synthesis. Therefor, sulfamethoxazole can inhibit the growth and replication of bacteria by blocking DNA synthesis. In addition, the synthesis of folate does not occur in humans, that is, sulfamethoxazole only acts on bacteria and not on the human body.